Retatrutide (GLP-3R)

Retatrutide (GLP-3R) — synthetic triple-agonist research peptide

Retatrutide is a synthetic triple-receptor agonist peptide studied for its activity at three metabolic receptors simultaneously: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and the glucagon receptor. This tri-agonist profile distinguishes it from dual agonists like tirzepatide (GIP/GLP-1) and mono-agonists like semaglutide (GLP-1 only), and makes it a subject of active research in receptor pharmacology, energy expenditure, and hepatic lipid metabolism.

Certificate of analysis — current lot on file

Retatrutide 10mg

• Product: Retatrutide 10mg
• Laboratory: Freedom Diagnostics (independent third party)
• Accession number: 2607150703
• Reported lot: RT10
• Reported purity: 99.52%
• Reported content: 12.82mg
• Report date: July 18, 2026

Retatrutide 20mg

• Product: Retatrutide 20mg
• Laboratory: Janoshik (independent third party)
• Task number: 200517
• Reported batch: RT20260602
• Reported purity: 99.507%
• Reported content: 22.24mg
• Report date: July 7, 2026

Verify these reports with the lab: open the original Freedom Diagnostics 10mg report and open the original Janoshik 20mg report. Both are also listed on the SBR Labs Certificates of Analysis page (10mg, 20mg). A report for the 15mg strength is not yet posted; please contact us before ordering if you need lot documentation for 15mg. To check the identity, lot, and purity fields yourself, see how to read a peptide certificate of analysis and how to verify peptide purity reports.

For laboratory research use only. Not for human or animal consumption. Retatrutide is an investigational research compound and is not approved by the FDA or any comparable regulator for any use.

Product specifications

• Class: synthetic triple-receptor agonist peptide (GLP-1 / GIP / glucagon)
• Amount per vial: 10mg, 15mg, or 20mg lyophilized powder (select strength above)
• Purity target: ≥98% by HPLC (third-party reports on file for 10mg and 20mg)
• Physical form: lyophilized white to off-white powder, sealed against light and moisture
• Reconstitution: commonly reconstituted with bacteriostatic water for laboratory work

Why the triple-agonist profile matters

Retatrutide's simultaneous activity at three receptors gives it a distinct research signature versus mono- and dual-agonist peptides:

• GLP-1 receptor — pancreatic beta-cell signaling, incretin-pathway effects, gastric emptying
• GIP receptor — additional incretin signaling and adipocyte energy handling
• Glucagon receptor — hepatic lipid metabolism, thermogenesis, and energy expenditure — a pathway absent from semaglutide and tirzepatide research

The glucagon-receptor component is what makes retatrutide of particular interest for research into hepatic lipid handling and energy-expenditure pathways.

Preclinical research areas

• Triple GLP-1 / GIP / glucagon receptor agonism in receptor-binding assays
• Energy expenditure and thermogenesis pathways in animal models
• Hepatic lipid metabolism and glucagon-receptor signaling research
• Incretin-pathway and pancreatic beta-cell signaling in vitro
• Gastric emptying and GI motility mechanism studies
• Pharmacokinetic and receptor-affinity characterization

Purity, testing, and COA

Independent third-party reports are on file for the 10mg strength (Freedom Diagnostics, lot RT10) and the 20mg strength (Janoshik, batch RT20260602). The 15mg report is not yet posted. Posted reports are available on the Certificates of Analysis page. To learn how to interpret a peptide COA, see the SBR Labs guide to reading a peptide COA.

Handling and reconstitution

• Store the sealed lyophilized vial at −20 °C, protected from light and moisture
• Reconstitute with bacteriostatic water or sterile water per your laboratory SOP
• After reconstitution, refrigerate at 2–8 °C and aliquot to single-use volumes
• Record lot number, reconstitution date, and solvent for reproducibility
• See the full SBR Labs handling & storage reference

Related research materials

• Tirzepatide (GLP-1T) 10mg — dual GIP/GLP-1 agonist for comparative research
• Semaglutide (GLP-1S) 10mg — GLP-1 mono-agonist reference
• Bacteriostatic Water 10ml — sterile diluent for reconstitution

For Laboratory Research Use Only. Not for human or veterinary use. Not a drug, dietary supplement, or cosmetic. Not intended to diagnose, treat, cure, or prevent any disease. Not for in-vivo use of any kind outside of a controlled research setting. Keep out of reach of children. By purchasing, you certify that you are a qualified researcher or research institution acquiring this product solely for in vitro laboratory research, and that you accept sole responsibility for compliance with all applicable local, state, and federal laws and regulations.