Semaglutide (GLP-1S) 10mg

Semaglutide (GLP-1S) 10mg — synthetic GLP-1 receptor agonist

Semaglutide is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist studied for its binding activity at the GLP-1 receptor. As a single-receptor agonist, it serves as the standard reference compound in comparative research against dual agonists (tirzepatide, GIP/GLP-1) and triple agonists (retatrutide, GIP/GLP-1/glucagon).

For laboratory research use only. Not for human or animal consumption. Semaglutide is offered here as a research reference material.

Product specifications

• Class: synthetic GLP-1 receptor mono-agonist peptide
• Amount per vial: 10mg lyophilized powder
• Purity target: ≥98% by HPLC (third-party verified per lot)
• Physical form: lyophilized white to off-white powder, sealed against light and moisture
• Reconstitution: commonly reconstituted with bacteriostatic water for laboratory work

Why semaglutide is the reference GLP-1 agonist in research

Semaglutide is the most-characterized GLP-1 mono-agonist in the modern research literature, which makes it the natural comparator for newer multi-agonist peptides:

• Receptor specificity — activity confined to the GLP-1 receptor, allowing clean isolation of GLP-1 pathway effects
• Downstream signaling — well-characterized cAMP/PKA activation pathway in beta-cell and enteric research models
• Comparator role — reference standard for evaluating incremental effects of GIP and glucagon receptor activity in dual- and triple-agonist research

Preclinical research areas

• GLP-1 receptor agonism in receptor-binding assays
• Incretin hormone signaling pathways in animal models
• Pancreatic beta-cell insulin secretion pathways in vitro
• Gastric emptying rate and GI motility mechanisms in animal models
• Downstream receptor signaling (cAMP/PKA pathway) in cell culture
• Pharmacokinetic and receptor-affinity characterization as a mono-agonist reference

Purity, testing, and COA

Every lot of semaglutide is characterized by an independent third-party laboratory. Each COA reports peptide identity by mass spectrometry, purity by reverse-phase HPLC, and appearance. Current and prior lot COAs are available at /pages/coas.

Handling and reconstitution

• Store the sealed lyophilized vial at −20 °C, protected from light and moisture
• Reconstitute with bacteriostatic water or sterile water per your laboratory SOP
• After reconstitution, refrigerate at 2–8 °C and aliquot to single-use volumes
• Record lot number, reconstitution date, and solvent for reproducibility
• See the full SBR Labs handling & storage reference

Related research materials

• Tirzepatide (GLP-1T) 10mg — dual GIP/GLP-1 agonist for comparative research
• Retatrutide (GLP-3R) 10mg — triple GLP-1 / GIP / glucagon agonist
• Bacteriostatic Water 10ml — sterile diluent for reconstitution

For Laboratory Research Use Only. Not for human or veterinary use. Not a drug, dietary supplement, or cosmetic. Not intended to diagnose, treat, cure, or prevent any disease. Not for in-vivo use of any kind outside of a controlled research setting. Keep out of reach of children. By purchasing, you certify that you are a qualified researcher or research institution acquiring this product solely for in vitro laboratory research, and that you accept sole responsibility for compliance with all applicable local, state, and federal laws and regulations.