{"title":"GLP-1 \u0026 Metabolic Research","description":"\u003cp\u003eGLP-1 agonist and dual\/triple-agonist research peptides including Semaglutide, Tirzepatide, and Retatrutide. Studied preclinically for metabolic and weight-regulation research. Third-party tested. For laboratory research use only.\u003c\/p\u003e","products":[{"product_id":"glp-3r","title":"Retatrutide (GLP-3R)","description":"\u003ch2\u003eRetatrutide (GLP-3R) — synthetic triple-agonist research peptide\u003c\/h2\u003e\n\n\u003cp\u003eRetatrutide is a synthetic \u003cstrong\u003etriple-receptor agonist\u003c\/strong\u003e peptide studied for its activity at three metabolic receptors simultaneously: \u003cstrong\u003eglucagon-like peptide-1 (GLP-1)\u003c\/strong\u003e, \u003cstrong\u003eglucose-dependent insulinotropic polypeptide (GIP)\u003c\/strong\u003e, and the \u003cstrong\u003eglucagon receptor\u003c\/strong\u003e. This tri-agonist profile distinguishes it from dual agonists like tirzepatide (GIP\/GLP-1) and mono-agonists like semaglutide (GLP-1 only), and makes it a subject of active research in receptor pharmacology, energy expenditure, and hepatic lipid metabolism.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eFor laboratory research use only.\u003c\/strong\u003e Not for human or animal consumption. Retatrutide is an investigational research compound and is not approved by the FDA or any comparable regulator for any use.\u003c\/p\u003e\n\n\u003ch3\u003eProduct specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eClass:\u003c\/strong\u003e synthetic triple-receptor agonist peptide (GLP-1 \/ GIP \/ glucagon)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAmount per vial:\u003c\/strong\u003e 10mg, 15mg, or 20mg lyophilized powder (select strength above)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity target:\u003c\/strong\u003e ≥98% by HPLC (third-party verified per lot)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhysical form:\u003c\/strong\u003e lyophilized white to off-white powder, sealed against light and moisture\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e commonly reconstituted with \u003ca href=\"https:\/\/sbresearchlabs.com\/products\/bac-water\"\u003ebacteriostatic water\u003c\/a\u003e for laboratory work\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy the triple-agonist profile matters\u003c\/h3\u003e\n\n\u003cp\u003eRetatrutide's simultaneous activity at three receptors gives it a distinct research signature versus mono- and dual-agonist peptides:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGLP-1 receptor\u003c\/strong\u003e — pancreatic beta-cell signaling, incretin-pathway effects, gastric emptying\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGIP receptor\u003c\/strong\u003e — additional incretin signaling and adipocyte energy handling\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucagon receptor\u003c\/strong\u003e — hepatic lipid metabolism, thermogenesis, and energy expenditure — a pathway absent from semaglutide and tirzepatide research\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eThe glucagon-receptor component is what makes retatrutide of particular interest for research into hepatic lipid handling and energy-expenditure pathways.\u003c\/p\u003e\n\n\u003ch3\u003ePreclinical research areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTriple GLP-1 \/ GIP \/ glucagon receptor agonism in receptor-binding assays\u003c\/li\u003e\n\u003cli\u003eEnergy expenditure and thermogenesis pathways in animal models\u003c\/li\u003e\n\u003cli\u003eHepatic lipid metabolism and glucagon-receptor signaling research\u003c\/li\u003e\n\u003cli\u003eIncretin-pathway and pancreatic beta-cell signaling in vitro\u003c\/li\u003e\n\u003cli\u003eGastric emptying and GI motility mechanism studies\u003c\/li\u003e\n\u003cli\u003ePharmacokinetic and receptor-affinity characterization\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003ePurity, testing, and COA\u003c\/h3\u003e\n\n\u003cp\u003eEvery lot of retatrutide is characterized by an independent third-party laboratory. Each COA reports peptide identity by mass spectrometry, purity by reverse-phase HPLC, and appearance. Current and prior lot COAs are available at \u003ca href=\"https:\/\/sbresearchlabs.com\/pages\/coas\"\u003e\/pages\/coas\u003c\/a\u003e. To learn how to interpret a peptide COA, see the \u003ca href=\"https:\/\/sbresearchlabs.com\/blogs\/news\/how-to-read-a-peptide-certificate-of-analysis\"\u003eSBR Labs guide to reading a peptide COA\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eHandling and reconstitution\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eStore the sealed lyophilized vial at −20 °C, protected from light and moisture\u003c\/li\u003e\n\u003cli\u003eReconstitute with bacteriostatic water or sterile water per your laboratory SOP\u003c\/li\u003e\n\u003cli\u003eAfter reconstitution, refrigerate at 2–8 °C and aliquot to single-use volumes\u003c\/li\u003e\n\u003cli\u003eRecord lot number, reconstitution date, and solvent for reproducibility\u003c\/li\u003e\n\u003cli\u003eSee the full \u003ca href=\"https:\/\/sbresearchlabs.com\/pages\/research-handling-storage-guide\"\u003eSBR Labs handling \u0026amp; storage reference\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eRelated research materials\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/sbresearchlabs.com\/products\/glp-1t\"\u003eTirzepatide (GLP-1T) 10mg\u003c\/a\u003e — dual GIP\/GLP-1 agonist for comparative research\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/sbresearchlabs.com\/products\/glp-1s\"\u003eSemaglutide (GLP-1S) 10mg\u003c\/a\u003e — GLP-1 mono-agonist reference\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/sbresearchlabs.com\/products\/bac-water\"\u003eBacteriostatic Water 10ml\u003c\/a\u003e — sterile diluent for reconstitution\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp style=\"text-align: center;\"\u003eFor Laboratory Research Use Only. Not for human or veterinary use. Not a drug, dietary supplement, or cosmetic. Not intended to diagnose, treat, cure, or prevent any disease. Not for in-vivo use of any kind outside of a controlled research setting. Keep out of reach of children. By purchasing, you certify that you are a qualified researcher or research institution acquiring this product solely for in vitro laboratory research, and that you accept sole responsibility for compliance with all applicable local, state, and federal laws and regulations.\u003c\/p\u003e","brand":"SBR Labs","offers":[{"title":"15mg","offer_id":53218181349743,"sku":"SBR-RETA-15MG","price":79.99,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":53224515273071,"sku":"SBR-RETA-10MG","price":64.99,"currency_code":"USD","in_stock":true},{"title":"20mg","offer_id":53511586382191,"sku":"SBR-RETA-20MG","price":119.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0976\/2491\/6335\/files\/IMG-4598.png?v=1785445086"},{"product_id":"glp-1t","title":"Tirzepatide (GLP-1T) 10mg","description":"\u003ch2\u003eTirzepatide (GLP-1T) 10mg — synthetic dual-agonist research peptide\u003c\/h2\u003e\n\n\u003cp\u003eTirzepatide is a synthetic \u003cstrong\u003edual-receptor agonist\u003c\/strong\u003e peptide studied for its binding activity at two metabolic receptors: \u003cstrong\u003eglucose-dependent insulinotropic polypeptide (GIP)\u003c\/strong\u003e and \u003cstrong\u003eglucagon-like peptide-1 (GLP-1)\u003c\/strong\u003e. This dual-incretin profile positions it between mono-agonists like semaglutide and triple-agonists like retatrutide, and makes it a common reference compound in comparative receptor-pharmacology research.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eFor laboratory research use only.\u003c\/strong\u003e Not for human or animal consumption. Tirzepatide is offered as a research reference material and is not approved by SBR Labs or by regulators for any human or veterinary use.\u003c\/p\u003e\n\n\u003ch3\u003eProduct specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eClass:\u003c\/strong\u003e synthetic dual GIP \/ GLP-1 receptor agonist peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAmount per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity target:\u003c\/strong\u003e ≥98% by HPLC (third-party verified per lot)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhysical form:\u003c\/strong\u003e lyophilized white to off-white powder, sealed against light and moisture\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e commonly reconstituted with \u003ca href=\"https:\/\/sbresearchlabs.com\/products\/bac-water\"\u003ebacteriostatic water\u003c\/a\u003e for laboratory work\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy dual GIP\/GLP-1 agonism matters in research\u003c\/h3\u003e\n\n\u003cp\u003eTirzepatide's simultaneous activity at both incretin receptors is what distinguishes it from single-receptor comparators like semaglutide:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGLP-1 receptor\u003c\/strong\u003e — pancreatic beta-cell insulin secretion pathways, gastric emptying, and cAMP\/PKA downstream signaling\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGIP receptor\u003c\/strong\u003e — additional incretin signaling not covered by GLP-1 mono-agonists, plus adipocyte lipid handling research\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCombined activity\u003c\/strong\u003e — reference research on dual-agonist pharmacokinetics, receptor-affinity ratios, and downstream signaling amplitude\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003ePreclinical research areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDual GIP\/GLP-1 receptor agonism in receptor-binding assays\u003c\/li\u003e\n\u003cli\u003eIncretin hormone signaling pathways in animal models\u003c\/li\u003e\n\u003cli\u003ePancreatic beta-cell insulin secretion pathways in vitro\u003c\/li\u003e\n\u003cli\u003eGastric emptying rate and GI motility mechanisms in animal models\u003c\/li\u003e\n\u003cli\u003eDownstream receptor signaling (cAMP\/PKA pathway) in cell culture\u003c\/li\u003e\n\u003cli\u003ePharmacokinetic and receptor-affinity characterization vs. GLP-1 mono-agonists\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003ePurity, testing, and COA\u003c\/h3\u003e\n\n\u003cp\u003eEvery lot of tirzepatide shipped by SBR Labs is characterized by an independent third-party laboratory. Each COA reports peptide identity by mass spectrometry, purity by reverse-phase HPLC, and appearance. Current and prior lot COAs are available at \u003ca href=\"https:\/\/sbresearchlabs.com\/pages\/coas\"\u003e\/pages\/coas\u003c\/a\u003e. For a walkthrough on interpreting a peptide COA, see the \u003ca href=\"https:\/\/sbresearchlabs.com\/blogs\/news\/how-to-read-a-peptide-certificate-of-analysis\"\u003eSBR Labs guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eHandling and reconstitution\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eStore the sealed lyophilized vial at −20 °C, protected from light and moisture\u003c\/li\u003e\n\u003cli\u003eReconstitute with bacteriostatic water or sterile water per your laboratory SOP\u003c\/li\u003e\n\u003cli\u003eAfter reconstitution, refrigerate at 2–8 °C and aliquot to single-use volumes\u003c\/li\u003e\n\u003cli\u003eRecord lot number, reconstitution date, and solvent for reproducibility\u003c\/li\u003e\n\u003cli\u003eSee the full \u003ca href=\"https:\/\/sbresearchlabs.com\/pages\/research-handling-storage-guide\"\u003eSBR Labs handling \u0026amp; storage reference\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eRelated research materials\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/sbresearchlabs.com\/products\/glp-1s\"\u003eSemaglutide (GLP-1S) 10mg\u003c\/a\u003e — GLP-1 mono-agonist for comparative research\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/sbresearchlabs.com\/products\/glp-3r\"\u003eRetatrutide (GLP-3R) 10mg\u003c\/a\u003e — triple agonist with added glucagon receptor activity\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/sbresearchlabs.com\/products\/bac-water\"\u003eBacteriostatic Water 10ml\u003c\/a\u003e — sterile diluent for reconstitution\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp style=\"text-align: center;\"\u003eFor Laboratory Research Use Only. Not for human or veterinary use. Not a drug, dietary supplement, or cosmetic. Not intended to diagnose, treat, cure, or prevent any disease. Not for in-vivo use of any kind outside of a controlled research setting. Keep out of reach of children. By purchasing, you certify that you are a qualified researcher or research institution acquiring this product solely for in vitro laboratory research, and that you accept sole responsibility for compliance with all applicable local, state, and federal laws and regulations.\u003c\/p\u003e","brand":"SBR Labs","offers":[{"title":"10mg","offer_id":53278073454959,"sku":"SBR-TIRZ-10MG","price":40.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0976\/2491\/6335\/files\/IMG-4564.png?v=1785381518"},{"product_id":"glp-1s","title":"Semaglutide (GLP-1S) 10mg","description":"\u003ch2\u003eSemaglutide (GLP-1S) 10mg — synthetic GLP-1 receptor agonist\u003c\/h2\u003e\n\n\u003cp\u003eSemaglutide is a synthetic \u003cstrong\u003eglucagon-like peptide-1 (GLP-1) receptor agonist\u003c\/strong\u003e studied for its binding activity at the GLP-1 receptor. As a single-receptor agonist, it serves as the standard reference compound in comparative research against dual agonists (tirzepatide, GIP\/GLP-1) and triple agonists (retatrutide, GIP\/GLP-1\/glucagon).\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eFor laboratory research use only.\u003c\/strong\u003e Not for human or animal consumption. Semaglutide is offered here as a research reference material.\u003c\/p\u003e\n\n\u003ch3\u003eProduct specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eClass:\u003c\/strong\u003e synthetic GLP-1 receptor mono-agonist peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAmount per vial:\u003c\/strong\u003e 10mg lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity target:\u003c\/strong\u003e ≥98% by HPLC (third-party verified per lot)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhysical form:\u003c\/strong\u003e lyophilized white to off-white powder, sealed against light and moisture\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e commonly reconstituted with \u003ca href=\"https:\/\/sbresearchlabs.com\/products\/bac-water\"\u003ebacteriostatic water\u003c\/a\u003e for laboratory work\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy semaglutide is the reference GLP-1 agonist in research\u003c\/h3\u003e\n\n\u003cp\u003eSemaglutide is the most-characterized GLP-1 mono-agonist in the modern research literature, which makes it the natural comparator for newer multi-agonist peptides:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceptor specificity\u003c\/strong\u003e — activity confined to the GLP-1 receptor, allowing clean isolation of GLP-1 pathway effects\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDownstream signaling\u003c\/strong\u003e — well-characterized cAMP\/PKA activation pathway in beta-cell and enteric research models\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eComparator role\u003c\/strong\u003e — reference standard for evaluating incremental effects of GIP and glucagon receptor activity in dual- and triple-agonist research\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003ePreclinical research areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGLP-1 receptor agonism in receptor-binding assays\u003c\/li\u003e\n\u003cli\u003eIncretin hormone signaling pathways in animal models\u003c\/li\u003e\n\u003cli\u003ePancreatic beta-cell insulin secretion pathways in vitro\u003c\/li\u003e\n\u003cli\u003eGastric emptying rate and GI motility mechanisms in animal models\u003c\/li\u003e\n\u003cli\u003eDownstream receptor signaling (cAMP\/PKA pathway) in cell culture\u003c\/li\u003e\n\u003cli\u003ePharmacokinetic and receptor-affinity characterization as a mono-agonist reference\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003ePurity, testing, and COA\u003c\/h3\u003e\n\n\u003cp\u003eEvery lot of semaglutide is characterized by an independent third-party laboratory. Each COA reports peptide identity by mass spectrometry, purity by reverse-phase HPLC, and appearance. Current and prior lot COAs are available at \u003ca href=\"https:\/\/sbresearchlabs.com\/pages\/coas\"\u003e\/pages\/coas\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eHandling and reconstitution\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eStore the sealed lyophilized vial at −20 °C, protected from light and moisture\u003c\/li\u003e\n\u003cli\u003eReconstitute with bacteriostatic water or sterile water per your laboratory SOP\u003c\/li\u003e\n\u003cli\u003eAfter reconstitution, refrigerate at 2–8 °C and aliquot to single-use volumes\u003c\/li\u003e\n\u003cli\u003eRecord lot number, reconstitution date, and solvent for reproducibility\u003c\/li\u003e\n\u003cli\u003eSee the full \u003ca href=\"https:\/\/sbresearchlabs.com\/pages\/research-handling-storage-guide\"\u003eSBR Labs handling \u0026amp; storage reference\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eRelated research materials\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/sbresearchlabs.com\/products\/glp-1t\"\u003eTirzepatide (GLP-1T) 10mg\u003c\/a\u003e — dual GIP\/GLP-1 agonist for comparative research\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/sbresearchlabs.com\/products\/glp-3r\"\u003eRetatrutide (GLP-3R) 10mg\u003c\/a\u003e — triple GLP-1 \/ GIP \/ glucagon agonist\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/sbresearchlabs.com\/products\/bac-water\"\u003eBacteriostatic Water 10ml\u003c\/a\u003e — sterile diluent for reconstitution\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp style=\"text-align: center;\"\u003eFor Laboratory Research Use Only. Not for human or veterinary use. Not a drug, dietary supplement, or cosmetic. Not intended to diagnose, treat, cure, or prevent any disease. Not for in-vivo use of any kind outside of a controlled research setting. Keep out of reach of children. By purchasing, you certify that you are a qualified researcher or research institution acquiring this product solely for in vitro laboratory research, and that you accept sole responsibility for compliance with all applicable local, state, and federal laws and regulations.\u003c\/p\u003e","brand":"SBR Labs","offers":[{"title":"10mg","offer_id":53479541342575,"sku":"SBR-SEMA-10MG","price":38.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0976\/2491\/6335\/files\/IMG-5319.png?v=1789496532"}],"url":"https:\/\/sbresearchlabs.com\/collections\/glp-1-metabolic-research.oembed","provider":"SBR Labs","version":"1.0","type":"link"}